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Many isomers of both A and B can be formed B OH OH OH 5-HETE COOH H H OH OH 5-HPETE O H OH COOH 5-HETE H OH COOH OH 5,15-DiHETE H OH H OH COOH Leukotriene A4 (LTA4) Glutathione C5H11 Foreex Glutathione S-transferase Leukotriene B4 (LTB4) H OH H S H OH S O H N HN H CO H NH3 Leukotriene C4 (LTC4) COOH H2O Glu COO C5H11 COOH O H N H3N H COO OOC Leukotriene D4 (LTD4) H2O Glycine H OH S COOH C5H11 H Figure 21-8 The 5-lipoxygenase pathway for biosynthesis of the hydroperoxy- and hydroxy- eicosanoic acids, leukotrienes, and lipoxins.
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